49ers vs. Eagles prediction, odds, spread, injuries, trends for NFL Week 13

A full betting preview for the Philadelphia Eagles' Week 13 matchup against the San Francisco 49ers.
Nov 26, 2023; Philadelphia, Pennsylvania, USA; Philadelphia Eagles quarterback Jalen Hurts (1)
Nov 26, 2023; Philadelphia, Pennsylvania, USA; Philadelphia Eagles quarterback Jalen Hurts (1) / Bill Streicher-USA TODAY Sports

The Philadelphia Eagles continue to find ways to win as they have four straight comeback wins. While those wins have been impressive, the Eagles will not try to play from behind on Sunday against the San Francisco 49ers in a rematch of last year’s NFC title game.

The 49ers have looked dominant since returning from their Week 9, ripping off three-straight double-digit wins against Jacksonville and Seattle. San Francisco is a short road favorite against the Eagles, which is surprising since the Eagles are 5-0 at home. 

Can the 49ers hand the Eagles’ first loss at home this season, or will Jalen Hurts have another MVP moment against one of the best teams in the NFC?

Below, we will break down this marquee matchup and provide our best bet for this NFC title game rematch between the 49ers and the Eagles.

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49ers vs. Eagles Odds, Spread and Total

49ers vs. Eagles Betting Trends

  • The 49ers are 3-3 ATS on the road this season
  • San Francisco is 6-1 ATS in its last seven games vs. NFC East opponents
  • Philadelphia is 3-1-1 ATS at home this season
  • The UNDER is 5-0 in the Eagles’ last five games against San Francisco

49ers vs. Eagles Injury Reports

49ers Injury Report

  • Spencer Burford - OT - Questionable
  • George Odum - S - IR

Eagles Injury Report

  • Milton Williams - DT - Questionable
  • Lane Johnson - OT - Questionable
  • Dallas Goedert - TE - Questionable
  • Grant Calcaterra - TE - Questionable
  • Zach Cunningham - LB - Questionable

49ers vs. Eagles How to Watch

  • Date: Sunday, Dec. 3
  • Game Time: 4:25 p.m. EST
  • Venue: Lincoln Financial Field
  • How to Watch (TV): FOX
  • 49ers Record: 8-3
  • Eagles Record: 10-1

49ers vs. Eagles Key Players to Watch

San Francisco 49ers

Christian McCaffrey: McCaffrey is coming off a stellar performance against the Seahawks on Thanksgiving night. The star running back had 139 total yards (114 rushing) and two rushing touchdowns on 24 touches. McCaffrey is a contender for Offensive Player of the Year, as he has a league-leading 16 total touchdowns (rushing/receiving). He’ll try to add to his total against the Eagles’ defense, which has been stout against the run this season.

Philadelphia Eagles

Jalen Hurts: Hurts had another MVP moment last week against the Bills as he led the Eagles back from a 10-point first-half deficit. The dynamic dual-threat quarterback completed 58.1% of his passes for 200 yards, three touchdowns, and an interception. He also had 65 rushing yards and two scores on the ground. Hurts has played outstanding in Philly’s last four games and must have another MVP-level performance against one of the best front sevens in the NFL.

49ers vs. Eagles Prediction and Pick

Based on how these two teams have played recently, it doesn’t come as a surprise to see the 49ers as short-road favorites. Since their Week 9 bye, San Francisco is scoring 30.6 points per game and holding opponents to 10 ppg. 

The addition of Chase Young at the deadline has made this 49ers’ defensive line unstoppable and hard to stop. Offensively, Brock Purdy has played turnover-free football, which has this team clicking on all cylinders. McCaffrey will give the Eagles’ defense issues out of the backfield, along with Brandon Aiyuk, who has scored a touchdown in three straight games.

The Niners haven’t been great ATS on the road (3-3) this season or in Philadelphia (2-9 ATS in their last 11 games), but they will give the Eagles everything they can handle.

Meanwhile, Philadelphia hopes to have All-Pro right tackle Lane Johnson back for Sunday’s game because having Jack Driscoll block Young or Nick Bosa is not ideal.

The Eagles need to get off to a fast start on Sunday, as they’ve only scored 14 first-half points in back-to-back games. They cannot afford to do that against San Francisco, as they won’t let up defensively, and they have an offense that can eat up the clock. 

The Eagles have surprisingly made it through the toughest part of their schedule with a perfect record thus far. Even though their defense has allowed 25 or more points in three out of their past four games. If Hurts and the offense can have a better start, they should cover the spread in one of the best games in Week 13.

Game odds refresh periodically and are subject to change.