Eagles vs Bills: 3 matchups where Philly has a distinct advantage, two more worth circling

Greg Rousseau, Von Miller versus Lane Johnson

The Bills like to use a nice rotation of Greg Rousseau and Von Miller on the left side of their defensive line. That means one thing. One of the best in the business, Lame Johnson, will need to visit the cold tub after this one.

Still, even with that being said, don't expect Rousseau and Miller to go off in this one.

Dane Jackson and Rasul Douglas vs. A.J. Brown and DeVonta Smith

Taron Johnson may be back for this one. He has been working his way back from a concussion, and his participation in Bills practice increased as the week went on. If he's ready, he'll play, but we'll throw Dane Jackson's name in the mix just in case.

Former Eagle Rasul Douglas hauled in an interception last week. He has played well since leaving Philly, but A.J. Brown and DeVonta Smith should enjoy big days in this one.

Efforts to get A.J. Brown involved are to be expected after a one-catch showing on Monday Night Football. We have all watched enough Eagles football to know that.

Brian Johnson vs. Sean McDermott and the Bills defense

The Bills don't employ an actual defensive coordinator. Instead, Sean Desai makes the calls on game day. Make no mistake about it. Brian Johnson has his work cut out for him, but the Eagles offense should be okay though.